Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/56183

Título:

Development and validation of a faecal immunochemical test-based model in the work-up of patients with iron deficiency anaemia

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Autor:

Hernández, Goretti
Quintero, Enrique
Morales-Arraez, Dalia
García Rayado, Guillermo
Hijos-Mallada, Gonzalo
Fernández-Fernández, Nereida
de Castro-Parga, Luisa
Álvarez-Sánchez, María Victoria
Olano, Carolina
Rodríguez-Alcalde, Daniel
Amaral-González, Carla
Alonso-Abreu, Inmaculada
Nicolás-Pérez, David
Carrillo-Palau, Marta
González-Dávila, Enrique
Gimeno-García, Antonio Z.

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Palabras clave:

Anaemia
Cancer-diagnosis
Colonoscopy
Colorectal cancer
Diagnostic tests
Endoscopy
Iron deficiency

Descriptores:

ANEMIA FERROPÉNICA
COLONOSCOPÍA
PRUEBAS DIAGNÓSTICAS DE RUTINA
DIAGNÓSTICO
GASTROSCOPÍA
DEFICIENCIAS DE HIERRO
ENDOSCOPÍA
NEOPLASIAS COLORRECTALES
DETECCIÓN PRECOZ DEL CÁNCER

Año de publicación:

2024

Contenido:

Resumen:

Objective: In patients with iron deficiency anaemia (IDA), the diagnostic yield of gastroscopy and colonoscopy (bidirectional endoscopy) in detecting neoplastic lesions is low. This study aimed to develop and validate a faecal immunochemical test (FIT)-based model to optimise the work-up of patients with IDA. Methods: Outpatients with IDA were enrolled in a prospective, multicentre study from April 2016 to October 2019. One FIT was performed before bidirectional endoscopy. Significant gastrointestinal lesions were recorded and a combined model developed with variables that were independently associated with significant colorectal lesions in the multivariate analysis. The model cut-off was selected to provide a sensitivity of at least 95% for colorectal cancer (CRC) detection, and its performance was compared to different FIT cut-offs. The data set was randomly split into two groups (developed and validation cohorts). An online calculator was developed for clinical application. Results: The development and validation cohorts included 373 and 160 patients, respectively. The developed model included FIT value, age, and sex. In the development and validation cohorts, a model cut-off of 0.1375 provided a negative predictive value of 98.1 and 96.7% for CRC and 90.7 and 88.3% for significant colorectal lesions, respectively. This combined model reduced the rate of missed significant colorectal lesions compared to FIT alone and could have avoided more than one-fourth of colonoscopies. Conclusion: The FIT-based combined model developed in this study may serve as a useful diagnostic tool to triage IDA patients for early endoscopic referral, resulting in considerable reduction of unnecessary colonoscopies.

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Frontiers Media

EN:

Frontiers in Medicine. 2024;11

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Citación:

Hernández G, Quintero E, Morales-Arraez D y otros. Development and validation of a faecal immunochemical test-based model in the work-up of patients with iron deficiency anaemia. Frontiers in Medicine [en línea]. 2024;11. 11 p.

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Licencia Creative Commons Atribución (CC - By 4.0)

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