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Título:

Transformers for genomic prediction.

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Autor:

Fariello, María Inés
Castro, Graciana
Hoffman, Romina
Musitelli, Mateo
Belzarena, Diego
Lecumberry, Federico

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Preprint

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Palabras clave:

Genomic Prediction
SNPs
genotype
phenotype
Neural Networks
Transformers

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Año de publicación:

2025

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Resumen:

AI is becoming state-of-the-art across scientific fields, giving novel solutions to age-old problems. In genomic prediction, Machine Learning methods could not outperform linear regressions in a general way yet, but are becoming closer. An important feature when working with genomic data, which is non other than a long sequence of information, is to account for the linkage disequilibrium, i.e. dependencies between genome variations that do not need to be close in the genome, and variate with respect to the reference genome. To explode this feature, we evaluate a Transformer trained in a small yeast dataset. Although it did not outperform the state-of-the-art results yet, the model got close achieving an R2 score of 0.389 and 0.400 in Lactate and Lactose ambients, respectively, comparing to the R2 score of 0.568 and 0.582 for Lactate and Lactose ambients, for the linear model of Lasso, proposed by [7].This proves that there is still room for improvement.

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Proyecto ANII : IA_1_2022_1_173411. Integración de datos genómicos y ambientales mediante aprendizaje profundo para selección genómica.

Citación:

Fariello, M., Castro, G., Hoffman, R. y otros. Transformers for genomic prediction [Preprint] Publicado en : Advances in Artificial Intelligence – IBERAMIA 2024. Lecture Notes in Computer Science, vol 15277. Springer, Cham. DOI : https://doi.org/10.1007/978-3-031-80366-6_11.

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https://hdl.handle.net/20.500.12008/49923

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Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)

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