Título:
Ameloblastic neoplasia spectrum : a cross-sectional study of MMPS expression and proliferative activity
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Autor:
da Silva, Alessandra Dutra
Nóbrega, TG
Saudades, AW
Otero, MI
Danilevicz, Chris Krebs
Magnusson, Alessandra Sellinger
Saraiva Homem de Carvalho, AL
Rados, Pantelis Varvaki
Carrard, Vinicius Coelho
Visioli, Fernanda
Sant'Ana Filho, Manoel
Nóbrega, TG
Saudades, AW
Otero, MI
Danilevicz, Chris Krebs
Magnusson, Alessandra Sellinger
Saraiva Homem de Carvalho, AL
Rados, Pantelis Varvaki
Carrard, Vinicius Coelho
Visioli, Fernanda
Sant'Ana Filho, Manoel
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Artículo
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Año de publicación:
2016
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Resumen:
Objective. To compare the proliferation and the expression of matrix metalloproteinases (MMPs; MMP-2 and MMP-9) in solid and unicystic ameloblastomas with ameloblastic carcinomas. Study Design.Five cases of ameloblastic carcinoma (AC), 18 cases of solid ameloblastoma (SA), and seven of unicystic ameloblastoma (UA) were selected. The immunohistochemical expression of MMPs was assessed by the percentage of positive tumor cells and stained stroma. The mean argyrophilic nucleolar organizer region (AgNOR) and the percentage of cells with more than one AgNOR per nucleus were evaluated. Results. Statistically significant higher mean AgNOR was observed in AC than in SA and UA. MMP-2 was expressed similarly in tumor and stroma among groups. MMP-9 was higher in the stroma of SA than that of UA (P = .0484). Conclusions. The cell proliferation was related to the greater aggressiveness of AC. High expression of MMP-2 and MMP-9 in all lesions highlighted the importance of these enzymes in the biology of ameloblastic tumors.
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Editorial:
Elsevier
EN:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Vol. 121, no.4., pp. 396-401
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Citación:
da Silva, A., Nóbrega, T., Saudades, A. y otros. "Ameloblastic neoplasia spectrum : a cross-sectional study of MMPS expression and proliferative activity". Oral Surgery [en linea]. 2016, Oral Medicine, Oral Pathology and Oral Radiology Vol. 121, no.4., pp. 396-401
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Licencia Creative Common Atribución (CC-BY)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| OteroMI_OOO.pdf | — | 1.06 MB | Adobe PDF |