| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Capoano Bevilacqua, Carlos Adrián | - |
| dc.contributor.author | Autor | Ortiz-Laquintana, Luis Adrián | - |
| dc.contributor.author | Autor | Rodríguez-Casuriaga, Rosana | - |
| dc.contributor.author | Autor | Schlapp, Geraldine | - |
| dc.contributor.author | Autor | Meikle, María Noel | - |
| dc.contributor.author | Autor | Mulet, Ana Paula | - |
| dc.contributor.author | Autor | Crispo, Martina | - |
| dc.contributor.author | Autor | Benavente, Ricardo | - |
| dc.contributor.author | Autor | Geisinger Wschebor, Adriana | - |
| dc.contributor.filiacion | Filiación | Capoano Bevilacqua Carlos Adrián, IIBCE | - |
| dc.contributor.filiacion | Filiación | Ortiz-Laquintana Luis Adrián, IIBCE | - |
| dc.contributor.filiacion | Filiación | Rodríguez-Casuriaga Rosana, IIBCE | - |
| dc.contributor.filiacion | Filiación | Schlapp Geraldine, Instituto Pasteur (Montevideo) | - |
| dc.contributor.filiacion | Filiación | Meikle María Noel, Instituto Pasteur (Montevideo) | - |
| dc.contributor.filiacion | Filiación | Mulet Ana Paula, Instituto Pasteur (Montevideo) | - |
| dc.contributor.filiacion | Filiación | Crispo Martina, Instituto Pasteur (Montevideo) | - |
| dc.contributor.filiacion | Filiación | Benavente Ricardo | - |
| dc.contributor.filiacion | Filiación | Geisinger Wschebor Adriana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
| dc.date.accessioned | Fecha ingreso | 2023-07-13T15:24:15Z | - |
| dc.date.available | Fecha disponible | 2023-07-13T15:24:15Z | - |
| dc.date.issued | Año de publicación | 2021 | - |
| dc.description.abstract | Resumen | SPATS1 (spermatogenesis-associated, serine-rich 1) is an evolutionarily conserved, testis-specific protein that is differentially expressed during rat male meiotic prophase. Some reports have suggested a link between SPATS1 underexpression/mutation and human pathologies such as male infertility and testicular cancer. Given the absence of functional studies, we generated a Spats1 loss-of-function mouse model using CRISPR/Cas9 technology. The phenotypic analysis showed no overt phenotype in Spats1-/- mice, with both males and females being fertile. Flow cytometry and histological analyses did not show differences in the testicular content and histology between WT and knockout mice. Moreover, no significant differences in sperm concentration, motility, and morphology, were observed between WT and KO mice. These results were obtained both for young adults and for aged animals. Besides, although an involvement of SPATS1 in the Wnt signaling pathway has been suggested, we did not detect changes in the expression levels of typical Wnt pathway-target genes in mutant individuals. Thus, albeit Spats1 alteration might be a risk factor for male testicular health, we hereby show that this gene is not individually essential for male fertility and spermatogenesis in mouse. | es |
| dc.format.extent | Extensión | 18 h | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Capoano Bevilacqua, C, Ortiz-Laquintana, L, Rodríguez-Casuriaga, R, [y otros autores]. "SPATS1 (spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse". PLoS ONE. [en línea] 2021, 16(5): e0251028. 18 h. | es |
| dc.identifier.doi | DOI | 10.1371/journal.pone.0251028 | - |
| dc.identifier.issn | ISSN | 1932-6203 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/38147 | - |
| dc.language.iso | Idioma | en | es |
| dc.publisher | Editorial | PloS ONE | es |
| dc.relation.ispartof | EN | PLoS ONE, 2021, 16(5): e0251028 | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución (CC - By 4.0) | es |
| dc.subject | Palabras clave | SPATS1 | es |
| dc.subject.other | Descriptores | ESPERMATOGENESIS | es |
| dc.subject.other | Descriptores | FERTILIDAD | es |
| dc.title | Título | SPATS1 (spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 101371journalpone0251028.pdf | — | 2.63 MB | Adobe PDF |