Título:
Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature
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Autor:
Silveira, Felipe Martins
Schuch, Lauren Frenzel
Pereira-Prado, Vanesa
Sicco, Estefanía
Almeda-Ojeda, Oscar
Molina-Frechero, Nelly
Paparella, María Luisa
Villarroel-Dorrego, Marina
Hernández, Marcela
Bologna-Molina, Ronell
Schuch, Lauren Frenzel
Pereira-Prado, Vanesa
Sicco, Estefanía
Almeda-Ojeda, Oscar
Molina-Frechero, Nelly
Paparella, María Luisa
Villarroel-Dorrego, Marina
Hernández, Marcela
Bologna-Molina, Ronell
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Tipo de documento:
Artículo
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Palabras clave:
Immunohistochemistry
Odontogenic tumors
Ameloblastoma
Odontogenic tumors
Ameloblastoma
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Año de publicación:
2024
Contenido:
Resumen:
Background: The initiation of odontogenic tumorigenesis often involves the activation of the MAP-kinase path-
way, with a pivotal role played by the BRAF V600E mutation. This study aimed to investigate the frequency of
BRAF V600E immunoexpresion in ameloblastomas diagnosed in four Latin American centers and correlate this
finding with the histological types and subtypes of the analyzed cases.Material and Methods: A total of 86 samples of ameloblastomas were examined for immunohistochemistry using anti-BRAF V600E antibody. The histopathological features of each case were analyzed. Results: Positivity for anti-BRAF V600E antibody was detected in 65/86 cases (75.6%). BRAF V600E was positive in 38/56 cases (67.9%) of conventional ameloblastomas and in 27/30 cases (90.0%) of unicystic ameloblastomas. A statistically significant difference in BRAF V600E positivity was observed when comparing unicystic ameloblastomas to conventional ameloblastomas (p=0.03). No statistically significant difference in BRAF V600E positivity was observed when comparing histological variants, both for conventional ameloblastomas and unicystic ameloblastomas.
Conclusions: This study highlights a high frequency of BRAF V600E immunoreactivity in ameloblastomas
among Latin American cases. The prevalence of the BRAF V600E immunoexpresion may suggest the feasibility
of utilizing BRAF-targeted therapy for ameloblastomas with this mutation.
Descripción:
Artículo disponible a texto completo a través de PubMed Central. Artículo head of print- article in press.
Editorial:
Medicina Oral S.L
EN:
Medicina Oral Patologia Oral y Cirugia Bucal, 2024.
Financiadores:
Comisión Sectorial de Investigación Científica - Uruguay; Agencia Nacional de Investigación e Innovación / Sistema Nacional de Investigadores - Uruguay.
Citación:
Silveira, F, Frenzel Schuch, L, Pereira-Prado, [y otros autores]. "Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature". Medicina Oral Patologia Oral y Cirugia Bucal. [en línea] 2024 .8 h.
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URI:
https://hdl.handle.net/20.500.12008/43627
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ISSN:
1698-6946
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Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 104317medoral26493.pdf | — | 1.23 MB | Adobe PDF |