Título:
Extended-spectrum β-lactamases, transferable quinolone resistance, and virulotyping in extra-intestinal E. coli in Uruguay
Otros títulos:
Coordinador:
Director:
Compilador:
Autor:
Vignoli, Rafael
García-Fulgueiras, Virginia
Cordeiro, Nicolás F.
Bado, Inés
Seija, Verónica
Aguerrebere, Paula
Laguna, Gabriel
Araújo, Lucía
Bazet, Cristina
Gutkind, Gabriel
Chabalgoity, Alejandro
García-Fulgueiras, Virginia
Cordeiro, Nicolás F.
Bado, Inés
Seija, Verónica
Aguerrebere, Paula
Laguna, Gabriel
Araújo, Lucía
Bazet, Cristina
Gutkind, Gabriel
Chabalgoity, Alejandro
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Virulence genes
ESBL
Plasmid-mediated quinolone resistance
ESBL
Plasmid-mediated quinolone resistance
Descriptores:
Año de publicación:
2016
Contenido:
Resumen:
Introduction: To characterize extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR) genes in Escherichia coliisolates obtained from extra-intestinal samples in three Uruguayan hospitals.Methodology: Fifty-five ESBL-producing E. coliisolates were studied. Virulence genes, ESBLs, and PMQR genes were detected by polymerase chain reaction. ESBL-producing isolates were compared by pulsed-field gel electrophoresis. Multi-locus sequence typing was also performed on 13 selected isolates.Results: Thirty-seven isolates harbored blaCTX-M-15(67.3%), eight blaCTX-M-2(14.6%), five blaCTX-M-14(9.1%), three carried both blaCTX-M-2 andblaCTX-M-14, one blaCTX-M-9, and oneblaCTX-M-8. Among the CTX-M-15 producers, 92% belonged to sequence types ST131 and ST405, and carried aac(6’)Ib-cras well. Isolates harboring blaCTX-M-2, blaCTX-M-14, blaCTX-M-9,or blaCTX-M-8were found to be genetically unrelated.Conclusions: The successful dissemination of CTX-M-15-producing E.coli isolates seems to be linked to the spreading of high-risk clones and horizontal gene transfer. A trade-off between carrying more antibiotic resistance and less virulence-related genes could partially account for the evolutionary advantages featured by successful clones.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
EN:
J Infect Dev Ctries. 10(1), 2016
Financiadores:
Comisión Sectorial de Investigación Científica (CSIC)
Citación:
VIGNOLI, R., GARCÍA-FULGUEIRAS, V., CORDEIRO, NF., y otros. Extended-spectrum β-lactamases, transferable quinolone resistance, and virulotyping in extra-intestinal E. coli in Uruguay. J Infect Dev Ctries [en línea] 2016, 10(1). DOI: 10.3855/jidc.6918
Citación:
metadata.articulos.cc.license.name:
ISBN:
e-ISBN:
ISSN:
ISMN:
Otros identificadores:
Cobertura geográfica:
Uruguay
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Extended-spectrum β-lactamases, transferable quinolone resistance, and virulotyping in extra-intestinal E. coli in Uruguay.pdf | Artículo original | 951.52 KB | Adobe PDF |