Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/55715

Título:

Genomic Diversity in Sporadic Breast Cancer in a Latin American Population

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Autor:

Brignoni, Lucía
Cappetta, Mónica
Colistro, Valentina
Sans, Mónica
Artagaveytia, Nora
Bonilla, Carolina
Bertoni, Bernardo

Tutor:

Tipo de documento:

Artículo

Editor:

Palabras clave:

Breast cancer
Population genetics
Latin America

Descriptores:

NEOPLASIAS DE LA MAMA
GENÉTICA DE POBLACIÓN
EPIDEMIOLOGÍA
MUJERES
ESTUDIOS DE CASOS Y CONTROLES
GENÉTICA
ESTUDIOS DE ASOCIACIÓN GENÉTICA
PERSONA DE MEDIANA EDAD
PREDISPOSICIÓN GENÉTICA A LA ENFERMEDAD
FACTORES DE RIESGO
POLIMORFISMO DE NUCLEÓTIDO SIMPLE

Año de publicación:

2020

Contenido:

Resumen:

Among Latin American women, breast cancer incidences vary across populations. Uruguay and Argentina have the highest rates in South America, which are mainly attributed to strong, genetic European contributions. Most genetic variants associated with breast cancer were described in European populations. However, the vast majority of genetic contributors to breast cancer risk remain unknown. Here, we report the results of a candidate gene association study of sporadic breast cancer in 176 cases and 183 controls in the Uruguayan population. We analyzed 141 variants from 98 loci that have been associated with overall breast cancer risk in European populations. We found weak evidence for the association of risk variants rs294174 (ESR1), rs16886165 (MAP3K1), rs2214681 (CNTNAP2), rs4237855 (VDR), rs9594579 (RANKL), rs8183919 (PTGIS), rs2981582 (FGFR2), and rs1799950 (BRCA1) with sporadic breast cancer. These results provide useful insight into the genetic susceptibility to sporadic breast cancer in the Uruguayan population and support the use of genetic risk scores for individualized screening and prevention.

Descripción:

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Editorial:

MDPI

EN:

Genes. 2020;11(11)

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Citación:

Brignoni L, Cappetta M, Colistro V y otros. Genomic Diversity in Sporadic Breast Cancer in a Latin American Population. Genes [en línea]. 2020;11(11). 12 p.

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Cobertura geográfica:

AMÉRICA LATINA
URUGUAY
ARGENTINA

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Licencia:

Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones Académicas y Científicas
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