Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/42129

Título:

Salmonella enterica Serovars Dublin and Enteritidis Comparative Proteomics Reveals Differential Expression of Proteins Involved in Stress Resistance, Virulence, and Anaerobic Metabolism

Otros títulos:

Coordinador:

Director:

Compilador:

Autor:

Martinez-Sanguiné, A. Y.
D’Alessandro, B.
Langleib, M.
Traglia, G. M.
Mónaco, A.
Durán, R.
Chabalgoity, J. A.
Betancor, L.
Yim, L.

Tutor:

Tipo de documento:

Artículo

Editor:

Palabras clave:

Comparative proteomics
Salmonella Dublin
Salmonella Enteritidis
Stress resistance
Virulence
Anaerobic metabolism

Descriptores:

Año de publicación:

2021

Contenido:

Resumen:

The Enteritidis and Dublin serovars of Salmonella enterica are phylogenetically closely related yet differ significantly in host range and virulence. S. Enteritidis is a broad-host-range serovar that commonly causes self-limited gastroenteritis in humans, whereas S. Dublin is a cattle-adapted serovar that can infect humans, often resulting in invasive extraintestinal disease. The mechanism underlying the higher invasiveness of S. Dublin remains undetermined. In this work, we quantitatively compared the proteomes of clinical isolates of each serovar grown under gut-mimicking conditions. Compared to S. Enteritidis, the S. Dublin proteome was enriched in proteins linked to response to several stress conditions, such as those encountered during host infection, as well as to virulence. The S. Enteritidis proteome contained several proteins related to central anaerobic metabolism pathways that were undetected in S. Dublin. In contrast to what has been observed in other extraintestinal serovars, most of the coding genes for these pathways are not degraded in S. Dublin. Thus, we provide evidence that S. Dublin metabolic functions may be much more affected than previously reported based on genomic studies. Single and double null mutants in stress response proteins Dps, YciF, and YgaU demonstrate their relevance to S. Dublin invasiveness in a murine model of invasive salmonellosis. All in all, this work provides a basis for understanding interserovar differences in invasiveness and niche adaptation, underscoring the relevance of using proteomic approaches to complement genomic studies

Descripción:

metadata.articulos.dc.description.uri:

Editorial:

EN:

Infection and Immunity. 2021, 89(3)

Financiadores:

Citación:

MARTINEZ-SANGUINÉ, A.Y., D'ALESSANDRO, B., LANGLEIB, M., y otros. Salmonella enterica Serovars Dublin and Enteritidis Comparative Proteomics Reveals Differential Expression of Proteins Involved in Stress Resistance, Virulence, and Anaerobic Metabolism. Infection and Immunity [en línea] 2021, 89(3). DOI: 10.1128/IAI.00606-20

Citación:

metadata.articulos.cc.license.name:

ISBN:

e-ISBN:

ISSN:

ISMN:

Otros identificadores:

Cobertura geográfica:

Cobertura temporal:

Departamento académico:

Grupo de investigación:

Licencia:

Licencia Creative Commons Atribución (CC - By 4.0)

Colecciones:

Artículos
FicherosDescripciónTamañoFormato
Salmonella.pdf Artículo original 2.09 MB Adobe PDF
Mostrar el registro Dublin Core completo del ítem

Licencia Creative Commons:

Licencia Creative Commons Atribución (CC - By 4.0)
Excepto donde se indique lo contrario, la licencia de este ítem se describe como Licencia Creative Commons Atribución (CC - By 4.0)