Título:
ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations
Otros títulos:
Coordinador:
Director:
Compilador:
Autor:
Duran-Merino, Denisse
Molina-Frechero, Nelly
Sánchez-Pérez, Leonor
Nevárez-Rascón, Martina
González González, Rogelio
Tremillo-Maldonado, Omar
Cassi, Diana
Bologna-Molina, Ronell
Molina-Frechero, Nelly
Sánchez-Pérez, Leonor
Nevárez-Rascón, Martina
González González, Rogelio
Tremillo-Maldonado, Omar
Cassi, Diana
Bologna-Molina, Ronell
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Genetic variation
Enamelin
Dental fluorosis
Caries
Enamelin
Dental fluorosis
Caries
Descriptores:
Año de publicación:
2020
Contenido:
Resumen:
The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. Methods: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher’s exact and Kruskal–Wallis tests. Results: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). Conclusion: The ENAM gene showed an association in the population exposed to different concentrations of fluoride
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
MDPI
EN:
International Journal of Environmental Research and Public Health, 17, 1832, 2020
Financiadores:
Citación:
Duran-Merino, D, Molina-Frechero, N, Sánchez-Pérez, L, y otros. "ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations". International Journal of Environmental Research and Public Health. [en línea] 2020, 17, 1832. doi:10.3390/ijerph17061832
Citación:
metadata.articulos.cc.license.name:
ISBN:
e-ISBN:
ISSN:
ISMN:
Otros identificadores:
Cobertura geográfica:
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Enam Gene 2020.pdf | — | 1.13 MB | Adobe PDF |