Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/55815

Título:

Differential admixture in Latin American populations and its impact on the study of colorectal cancer

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Autor:

Colistro, Valentina
Mut, Patricia
Hidalgo, Pedro C.
Carracedo, Ángel
Quintela, Inés
Rojas-Martínez, Augusto
Sans, Mónica

Tutor:

Tipo de documento:

Artículo

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Palabras clave:

Admixture
Genetic ancestry
Heterozygosity
Latin America populations

Descriptores:

GENÉTICA
PÉRDIDA DE HETEROCIGOCIDAD
VARIACIÓN GENÉTICA
POBLACIÓN
GRUPOS DE POBLACIÓN
RELACIONES RACIALES
ESTUDIO DE ASOCIACIÓN DEL GENOMA COMPLETO

Año de publicación:

2020

Contenido:

Resumen:

Genome-wide association studies focused on searching genes responsible for several diseases. Admixture mapping studies proposed a more efficient alternative capable of detecting polymorphisms contributing with a small effect on the disease risk. This method focuses on the higher values of linkage disequilibrium in admixed populations. To test this, we analyzed 10 genomic regions previously defined as related with colorectal cancer among nine populations and studied the variation pattern of haplotypic structures and heterozygosity values on seven categories of SNPs. Both analyses showed differences among chromosomal regions and studied populations. Admixed Latin-American samples generally show intermediate values. Heterozygosity of the SNPs grouped in categories varies more in each gene than in each population. African related populations have more blocks per chromosomal region, coherently with their antiquity. In sum, some similarities were found among Latin American populations, but each chromosomal region showed a particular behavior, despite the fact that the study refers to genes and regions related with one particular complex disease. This study strongly suggests the necessity of developing statistical methods to deal with di- or tri-hybrid populations, as well as to carefully analyze the different historic and demographic scenarios, and the different characteristics of particular chromosomal regions and evolutionary forces.

Descripción:

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Editorial:

Sociedade Brasileira de Genética

EN:

Genetics and Molecular Biology. 2020;43(4)

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Citación:

Colistro V, Mut P, Hidalgo P y otros. Differential admixture in Latin American populations and its impact on the study of colorectal cancer. Genetics and Molecular Biology [en línea]. 2020;43(4). 9 p.

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Cobertura geográfica:

AMÉRICA LATINA

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Licencia:

Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones Académicas y Científicas
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