Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/49601

Título:

Temperature‑dependent iron motion in extremophile rubredoxins – no need for ‘corresponding states’

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Autor:

Jenney Jr, Francis E.
Wang, Hongxin
George, Simon J.
Xiong, Jin
Guo, Yisong
Gee, Leland B.
Marizcurrena, Juan José
Castro-Sowinski, Susana
Staskiewicz, Anna
Yoda, Yoshitaka
Hu, Michael Y.
Tamasaku, Kenji
Nagasawa, Nobumoto
Li, Lei
Matsuura, Hiroaki
Doukov, Tzanko
Cramer, Stephen P.

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Artículo

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Palabras clave:

Rubredoxin
Iron-Sulfur
Extremophile
Hyperthermophile
Psychrophile
Corresponding States

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Año de publicación:

2024

Contenido:

Resumen:

Extremophile organisms are known that can metabolize at temperatures down to − 25 °C (psychrophiles) and up to 122 °C (hyperthermophiles). Understanding viability under extreme conditions is relevant for human health, biotechnological applications, and our search for life elsewhere in the universe. Information about the stability and dynamics of proteins under environmental extremes is an important factor in this regard. Here we compare the dynamics of small Fe‑S proteins – rubredoxins – from psychrophilic and hyperthermophilic microorganisms, using three different nuclear techniques as well as molecular dynamics calculations to quantify motion at the Fe site. The theory of ‘corresponding states’ posits that homologous proteins from different extremophiles have comparable flexibilities at the optimum growth temperatures of their respective organisms. Although ‘corresponding states’ would predict greater flexibility for rubredoxins that operate at low temperatures, we find that from 4 to 300 K, the dynamics of the Fe sites in these homologous proteins are essentially equivalent.

Descripción:

Información suplementaria en: https://doi.org/10.1038/s41598-024-62261-2.

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Editorial:

Nature

EN:

Scientific reports, 2024, 14: 12197.

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Citación:

Jenney Jr, F, Wang, H, George, S [y otros autores]. "Temperature‑dependent iron motion in extremophile rubredoxins – no need for ‘corresponding states’". Scientific reports. [en línea] 2024, 14: 12197. 12 h. DOI: 10.1038/s41598-024-62261-2

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2045-2322

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones académicas y científicas
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