Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/54961

Título:

Epidemiology and Risk Factors for the Development of Infectious Complications in Newly Diagnosed Multiple Myeloma: A Multicenter Prospective Cohort Study in Latin America

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Autor:

Bove, Virginia
Riva, Eloísa
Vásquez, Jule
Peña, Camila
Seehaus, Cristian
Samanez, César
Bustos, Justina
Hernández, Marcos
Fernández, Julio
Ríos, Oliday
Rodríguez, Yusaima
Figueredo, Irving
Fantl, Dorotea
Malpica, Luis

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EPIDEMIOLOGÍA
FACTORES DE RIESGO
MIELOMA MÚLTIPLE
ESTUDIOS PROSPECTIVOS
INFECCIONES BACTERIANAS
INDICADORES DE MORBIMORTALIDAD
ANTIBACTERIANOS

Año de publicación:

2022

Contenido:

Resumen:

Infections are a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in this patient population are lacking. METHODS We conducted a prospective cohort study of patients with newly diagnosed MM (NDMM) in seven Latin American countries between June 2019 and May 2020. Patients with active disease, on active therapy, and with a follow-up of 6 months from the time of diagnosis were included. Our primary end point was the number of infectious events that required hospitalization for ≥ 24 hours. RESULTS Of 248 patients with NDMM, 89 (35.9%) had infectious complications (113 infectious events), the majority (67.3%) within the first 3 months from diagnosis. The most common sites of infection were respiratory (38%) and urinary tract (31%). The microbial agent was identified in 57.5% of patients with gram-negative bacteria (73.5%) as the most common pathogen. Viral infections were infrequent, and no patients with fungal infection were reported. In the multivariable analysis, diabetes mellitus (odds ratio [OR], 2.71; 95% CI, 1.23 to 6.00; P = .014), creatinine ≥ 2 mg/dL (OR, 4.87; 95% CI, 2.29 to 10.35; P < .001), no use of trimethoprim-sulfamethoxazole prophylaxis (OR, 6.66; 95% CI, 3.43 to 12.92; P < .001), and treatment with immunomodulatory drugs (OR, 3.02; 95% CI, 1.24 to 6.29; P = .003) were independent factors associated with bacterial infections. At 6 months, 21 patients (8.5%) had died, 47.6% related to infectious complications. CONCLUSION Bacterial infections are a substantial cause of hospital admissions and early death in patients with NDMM. Antibiotic prophylaxis should be considered to reduce infectious complications in patients with MM.

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Editorial:

American Society of Clinical Oncology

EN:

JCO Global Oncology. 2022;8

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Citación:

Bove V, Riva E, Vásquez J y otros. Epidemiology and Risk Factors for the Development of Infectious Complications in Newly Diagnosed Multiple Myeloma: A Multicenter Prospective Cohort Study in Latin America. JCO Global Oncology [en línea]. 2022;8. 10 p.

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Cobertura geográfica:

AMÉRICA LATINA

Cobertura temporal:

2019 - 2020

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Licencia:

Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)

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