Título:
Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
Otros títulos:
Coordinador:
Director:
Compilador:
Autor:
González Galván, María del Carmen
Mosqueda Taylor, Adalberto
Bologna-Molina, Ronell
Setien Olarra, Amaia
Marichalar Mendia, Xabier
Aguirre Urizar, José Manuel
Mosqueda Taylor, Adalberto
Bologna-Molina, Ronell
Setien Olarra, Amaia
Marichalar Mendia, Xabier
Aguirre Urizar, José Manuel
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Odontogenic myxoma
Dental follicle
RANK
RANK-L
OPG
Osteoclastogenesis.
Dental follicle
RANK
RANK-L
OPG
Osteoclastogenesis.
Descriptores:
OSTEOGENESIS
LIGANDO RANK
MIXOMA
LIGANDO RANK
MIXOMA
Año de publicación:
2018
Contenido:
Resumen:
Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms.
RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor
activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANK-L / OPG system participates in the
regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone
destruction, and also with tumor growth. Objectives: To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size.
Material and Methods: Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were
included as control were studied by means of standard immunohistochemical procedure with RANK, RANK-L
and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where
the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results: There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions: Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
EN:
Med Oral Patol Oral Cir Bucal. 2018 May 1;23 (3):e315-9.
Financiadores:
Citación:
González Galván, M, Mosqueda Taylor, A, Bologna-Molina, R. y otros "Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas"Med Oral Patol Oral Cir Bucal. 2018 May 1;23 (3):e315-9. [en línea] 2018.doi:10.4317/medoral.22372
Citación:
metadata.articulos.cc.license.name:
ISBN:
e-ISBN:
ISSN:
ISMN:
Otros identificadores:
Cobertura geográfica:
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Evaluation of the osteoclastogenic process associated with RANK RANK-L OPG in odontogenic myxomas.pdf | — | 598.48 KB | Adobe PDF |