Título:
Infecciones bacterianas durante el primer mes post trasplante hepático. Experiencia de 12 años en un único centro. Montevideo-Uruguay
Otros títulos:
Bacterial infections during the first month after liver transplantation. 12 years experience in a single center. Montevideo-Uruguay
Coordinador:
Director:
Compilador:
Autor:
Prieto, Jimena
Abaracón, Camila
López, Martín
Medina, Julio
Abaracón, Camila
López, Martín
Medina, Julio
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Trasplante hepático
Infección bacteriana
Morbimortalidad
Liver transplant
Infectious complication
Mortality
Infección bacteriana
Morbimortalidad
Liver transplant
Infectious complication
Mortality
Descriptores:
TRASPLANTE DE HÍGADO
INFECCIONES BACTERIANAS
INDICADORES DE MORBIMORTALIDAD
MORTALIDAD
INFECCIONES BACTERIANAS
INDICADORES DE MORBIMORTALIDAD
MORTALIDAD
Año de publicación:
2023
Contenido:
Resumen:
Introducción: Las infecciones bacterianas en trasplante hepático (TH) son una de las principales causas de morbimortalidad. Objetivo: Caracterizar las complicaciones infecciosas bacterianas en el primer mes postrasplante. Pacientes y Métodos: Estudio retrospectivo entre los años 2009-2020. Resultados: 225 pacientes recibieron un TH. 80 (35,5%) desarrollaron al menos un episodio de infección bacteriana en el primer mes postrasplante hepático. Hubo 105 episodios de infección bacteriana con una incidencia de 46,6%. El foco más frecuente fue el abdominal (48,6%) y el microorganismo predominante fue Klebsiella spp. De los 104 aislamientos, el 57,6% presentaron un perfil MDR/XDR. Los pacientes que desarrollaron una complicación infecciosa presentaron menor sobrevida al alta hospitalaria en comparación con los que no la presentaron 87,5 versus 94,5% [OR 4,18 (IC 95%: 1,5-11,6)]. En el análisis multivariado la reintervención quirúrgica precoz [OR 4,286 (IC 95%: 1,911-9,61)], mostró un riesgo significativo de desarrollar una complicación infecciosa bacteriana en el primer mes postrasplante. Conclusiones: Tres de cada 10 pacientes presentaron una infección bacteriana en el primer mes postrasplante con una alta incidencia de bacilos gramnegativos MDR/XDR. Los pacientes que desarrollaron una complicación infecciosa presentaron una menor sobrevida al alta. La reintervención quirúrgica precoz se identificó como un factor predisponente de infección temprana.
Background: Bacterial infections are one of the main causes of morbidity and mortality in liver transplant recipients (LT). Aim: To characterize bacterial infectious complications in the first month an after a liver transplant. Methods: Retrospective analysis of a cohort of liver transplant recipients who presented at least one bacterial infectious complication in the first month after transplant between 2009 and 2020. Results: 225 patients were analyzed. 80 (35.5%) had a least one documented bacterial infection during the first month after transplant. 105 bacterial infections were documented, with an incidence of 46.6%. The most frequent origin was intra-abdominal (48.6%) and the predominant isolated microorganism was Klebsiella spp. Among 104 isolated microorganisms 57.6% showed MDR/XDR profile. Patients who developed a bacterial infectious complication had a shorter overall survival (OS) after discharge from hospital (87.5% vs 94.5%) [OR 4.18 (IC 95%: 1.5-11,6)]. When multivariate analysis of predisposing factors was performed early surgical reoperation was the only variable associated with an increased risk of developing a bacterial complication in the first month [OR 4.286 (IC 95%: 1.911-9.61)]. Conclusions: Three out of 10 patients developed a bacterial infectious complication during the first month after liver transplant with a high incidence of gram-negative bacillus MDR/XDR. Patients who presented infectious complications had a shorter OS after discharge, and early reoperation was identified as a predisposing factor of early infectious complications.
Background: Bacterial infections are one of the main causes of morbidity and mortality in liver transplant recipients (LT). Aim: To characterize bacterial infectious complications in the first month an after a liver transplant. Methods: Retrospective analysis of a cohort of liver transplant recipients who presented at least one bacterial infectious complication in the first month after transplant between 2009 and 2020. Results: 225 patients were analyzed. 80 (35.5%) had a least one documented bacterial infection during the first month after transplant. 105 bacterial infections were documented, with an incidence of 46.6%. The most frequent origin was intra-abdominal (48.6%) and the predominant isolated microorganism was Klebsiella spp. Among 104 isolated microorganisms 57.6% showed MDR/XDR profile. Patients who developed a bacterial infectious complication had a shorter overall survival (OS) after discharge from hospital (87.5% vs 94.5%) [OR 4.18 (IC 95%: 1.5-11,6)]. When multivariate analysis of predisposing factors was performed early surgical reoperation was the only variable associated with an increased risk of developing a bacterial complication in the first month [OR 4.286 (IC 95%: 1.911-9.61)]. Conclusions: Three out of 10 patients developed a bacterial infectious complication during the first month after liver transplant with a high incidence of gram-negative bacillus MDR/XDR. Patients who presented infectious complications had a shorter OS after discharge, and early reoperation was identified as a predisposing factor of early infectious complications.
Descripción:
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Editorial:
Elsevier
EN:
Revista Chilena de Infectología. 2023;40(5):529-536
Financiadores:
Citación:
Prieto J, Abaracón C, López M y otros. Infecciones bacterianas durante el primer mes post trasplante hepático. Experiencia de 12 años en un único centro. Montevideo-Uruguay. Revista Chilena de Infectología [en línea]. 2023;40(5):529-536
Citación:
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ISBN:
e-ISBN:
ISSN:
ISMN:
Otros identificadores:
Cobertura geográfica:
URUGUAY
MONTEVIDEO
MONTEVIDEO
Cobertura temporal:
2009 - 2020
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Infecciones bacterianas durante el primer mes post trasplante hepático.pdf | Infecciones bacterianas durante el primer mes post trasplante hepático | 1.56 MB | Adobe PDF |