Título:
Oxidative stress in healthy and pathological red blood cells
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Autor:
Orrico, Florencia
Laurance, Sandrine
López Royes, Ana Clara
Lefevre, Sophie D.
Thomson, Leonor
Möller, Matías N.
Ostuni, Mariano A.
Laurance, Sandrine
López Royes, Ana Clara
Lefevre, Sophie D.
Thomson, Leonor
Möller, Matías N.
Ostuni, Mariano A.
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Tipo de documento:
Artículo
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Palabras clave:
Erythrocyte
Reactive oxygen species
Antioxidant
Oxidative stress
Sickle cell disease
Glucose 6-phosphate dehydrogenase deficiency
Pyruvate kinase deficiency
Reactive oxygen species
Antioxidant
Oxidative stress
Sickle cell disease
Glucose 6-phosphate dehydrogenase deficiency
Pyruvate kinase deficiency
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Año de publicación:
2023
Contenido:
Resumen:
Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygencarrying capacity. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense mechanisms, plays a significant role in the pathophysiology of red cell diseases. In this review, we discuss the most relevant oxidant species involved in RBC damage, the enzymatic and low molecular weight antioxidant systems that protect RBCs against oxidative injury, and finally, the role of oxidative stress in different red cell diseases, including sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, and pyruvate kinase deficiency, highlighting the underlying mechanisms leading to pathological RBC phenotypes.
Descripción:
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MDPI
EN:
Biomolecules, 2023, 13(8): 1262.
Financiadores:
CSIC: I+D_2020_557
Citación:
Orrico, F, Laurance, S, López Royes, A [y otros autores]. "Oxidative stress in healthy and pathological red blood cells". Biomolecules. [en línea] 2023, 13(8): 1262. 20 h. DOI: 10.3390/biom13081262.
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ISSN:
2218-273X
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.3390.biom13081262.pdf | — | 1.38 MB | Adobe PDF |