| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Bologna-Molina, Ronell | - |
| dc.contributor.author | Autor | Pereira-Prado, Vanesa | - |
| dc.contributor.author | Autor | Sánchez-Romero, Celeste | - |
| dc.contributor.author | Autor | Tapia-Repetto, Gabriel | - |
| dc.contributor.author | Autor | Soria, Sandra | - |
| dc.contributor.author | Autor | Hernandez, Marcela | - |
| dc.contributor.author | Autor | Gónzalez Gónzalez, Rogelio | - |
| dc.contributor.author | Autor | Molina-Frechero, Nelly | - |
| dc.contributor.author | Autor | Mikami, Toshinari | - |
| dc.contributor.filiacion | Filiación | Bologna-Molina Ronell, Molecular Pathology Area, Faculty of Dentistry, Universidad de la Republica, Montevideo, Uruguay | - |
| dc.contributor.filiacion | Filiación | Pereira-Prado Vanesa, Molecular Pathology Area, Faculty of Dentistry, Universidad de la Republica, Montevideo, Uruguay | - |
| dc.contributor.filiacion | Filiación | Sánchez-Romero Celeste, Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil | - |
| dc.contributor.filiacion | Filiación | Tapia-Repetto Gabriel, Histology Area, Faculty of Dentistry, Universidad de la Republica, Montevideo, Uruguay | - |
| dc.contributor.filiacion | Filiación | Soria Sandra, Molecular Pathology Area, Faculty of Dentistry, Universidad de la Republica, Montevideo, Uruguay | - |
| dc.contributor.filiacion | Filiación | Hernandez Marcela, Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile/ Dentistry Unit, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile | - |
| dc.contributor.filiacion | Filiación | Gónzalez Gónzalez Rogelio, Oral Pathology and Medicine Department, Universidad Juárez del Estado de Durango, México | - |
| dc.contributor.filiacion | Filiación | Molina Frechero Nelly, Health Care Department, Universidad Autónoma Metropolitana, México | - |
| dc.contributor.filiacion | Filiación | Mikami Toshinari, Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Morioka, Japan | - |
| dc.date.accessioned | Fecha ingreso | 2022-05-05T12:56:48Z | - |
| dc.date.available | Fecha disponible | 2022-05-05T12:56:48Z | - |
| dc.date.issued | Año de publicación | 2018 | - |
| dc.description.abstract | Resumen | Mismatch repair proteins (MMRPs) are a group of nuclear enzymes that participate in the repair of base mismatches that occur during DNA replication in all proliferating cells. The most studied MMRPs are hMSH2 and hMLH1, which are known to be highly expressed in normal tissues. A loss of MMRPs leads to the accumulation of DNA replication errors in proliferating cells. Ki-67 is a biomarker regarded to be the gold-standard tool for determining cell proliferation by immunohistochemical methods. The aim of this study was to investigate the immunohistochemical expression of hMLH1, hMSH2 and Ki-67 proteins in ameloblastomas and tooth germs, to contribute to the understanding of the development of this odontogenic neoplasm. Material and Methods: Immunohistochemical assays to determine the presence of proteins hMSH2, hMLH1 andKi-67 were performed in 80 ameloblastomas (40 solid and 40 unicystic) and five tooth germs. Results: Unicystic ameloblastomas showed higher MMRP expression (hMLH1: 62.5 ± 43.4; hMSH2: 83.3 ± 47.8) than did solid ameloblastomas (hMLH1: 59.4 ± 13.5; hMSH2: 75.8 ± 40.2). Additionally, the cell proliferation index assessed by Ki-67 was inversely proportional to the expression of MMRP. Comparison between tooth germs and ameloblastoma revealed significantly higher expression of hMLH1, hMSH2 and Ki-67 in tooth germs (p=0.02). Conclusions: The differences of MMRP and Ki-67 immunoexpression between ameloblastomas and tooth germ suggest that alterations in the MMRP mechanisms could participate in the biological behavior of ameloblastomas. | es |
| dc.format.extent | Extensión | e126-131 | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Bologna-Molina, R, Pereira-Prado, V, Sánchez-Romero, C. y otros . "Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs"Med Oral Patol Oral Cir Bucal. 2018 Mar 1;23 (2):e126-31. [en línea] 2018. e126-131. doi:10.4317/medoral.22210 | es |
| dc.identifier.doi | DOI | doi:10.4317/medoral.22210 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/31431 | - |
| dc.language.iso | Idioma | en | es |
| dc.relation.ispartof | EN | Med Oral Patol Oral Cir Bucal. 2018 Mar 1;23 (2):e126-31. | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0) | es |
| dc.subject | Palabras clave | hMLH1 | es |
| dc.subject | Palabras clave | hMSH2 | es |
| dc.subject | Palabras clave | Ki-67 | es |
| dc.subject | Palabras clave | Ameloblastomas | es |
| dc.subject | Palabras clave | Tooth germs | es |
| dc.subject.other | Descriptores | GERMEN DENTARIO | es |
| dc.subject.other | Descriptores | AMELOBLASTOMA | es |
| dc.subject.other | Descriptores | ANTIGENO Ki-67 | es |
| dc.subject.other | Descriptores | PROTEINA 2 HOMOLOGA a MutS (1) | es |
| dc.subject.other | Descriptores | HOMOLOGO 1 DE LA PROTEINA MutL (1) | es |
| dc.title | Título | Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs.pdf | — | 1.99 MB | Adobe PDF |