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Título:

Genetic and antigenic diversity of Bubaline alphaherpesvirus 1

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Autor:

Tau, Rocío Lucia
Marandino, Ana
Torales, Fátima
Souza Campos, Fabrício
Roehe, Paulo Michel
Konrad, José Luis
Romera, Sonia Alejandra
Pérez Crossa, Ruben Gustavo
Maidana, Silvina Soledad

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Artículo

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Palabras clave:

Bubaline alphaherpesvirus 1
Genetic diversity
Antigenic variation
Cross-neutralization
Phylogenetic analysis
Recombination
Water buffalo

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Año de publicación:

2025

Contenido:

Resumen:

Bubaline alphaherpesvirus 1 (BuHV-1) is a virus that belongs to the Varicellovirus genus within the Alphaherpesvirinae subfamily. While BuHV-1 infections in water buffaloes (Bubalusbubalis) are often subclinical, clinical manifestations have been reported. This study provides complete genome sequences of five BuHV-1 strains isolated in Argentina, marking the first genomic characterization of BuHV-1 from the Americas. Phylogenetic reconstructions based on whole-genome and coding sequences, along with analyses of glycoproteins C, D, and E, identified a distinct clade and divergent strains. Comparative genomic analyses with publicly available BuHV-1 and Bovine alphaherpesvirus 5 (BoHV-5) sequences showed nucleotide divergence of up to 1.3% among BuHV-1 strains, indicating significant intraspecific genetic diversity. Cross-neutralization assays revealed variable relationships between BuHV-1 and BoHV-5 strains. Some Argentinian BuHV-1 strains exhibited significant anti- genic subtype differences compared to Bovine alphaherpesvirus 1 (BoHV-1). Recombination analyses uncovered events between BuHV-1 and bovine herpesviruses, suggesting a complex evolutionary history within mixed farming systems. The findings indicate that the monophyletic BuHV-1 clade, including the reference BuHV-1 isolate, is representative of the BuHV-1 species. The remaining strains, provisionally classified as BuHV-1 indeterminate (BuHV-1i), can be categorized based on specific clinical and antigenic properties. The identified heterogeneity has significant implications for diagnostic accuracy, vaccine development, and disease management strategies in buffalo populations worldwide.

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MDPI

EN:

Viruses, 2025, 17(8): 1110.

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ANII: FCE_1_2019_1_156578

Citación:

Tau, R, Marandino, A, Torales, F [y otros autores]. "Genetic and antigenic diversity of Bubaline alphaherpesvirus 1". Viruses. [en línea] 2025, 17(8): 1110. 12 h. DOI: 10.3390/v17081110

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1999-4915

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Licencia Creative Commons Atribución (CC - By 4.0)

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