Título:
Plasticity of cell proliferation in the retina of Austrolebias charrua fish under light and darkness conditions
Otros títulos:
Coordinador:
Director:
Compilador:
Autor:
Berrosteguieta Rodríguez, Inés
Rosillo Martí, Juan Carlos
Herrera, María Laura
Olivera-Bravo, Silvia
Casanova, Gabriela
Herránz-Pérez, Vicente
García-Verdugo, José Manuel
Fernández Constenla, Anabel Sonia
Rosillo Martí, Juan Carlos
Herrera, María Laura
Olivera-Bravo, Silvia
Casanova, Gabriela
Herránz-Pérez, Vicente
García-Verdugo, José Manuel
Fernández Constenla, Anabel Sonia
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Stem cell
Fish brain
Rods
Ciliary marginal zone
Fish brain
Rods
Ciliary marginal zone
Descriptores:
Año de publicación:
2022
Contenido:
Resumen:
Austrolebias annual fishes exhibit cell proliferation and neurogenesis throughout life. They withstand extreme environmental changes as their habitat dries out, pressuring nervous system to adapt. Their visual system is
challenged to adjust as the water becomes turbid. Therefore, this study focused on how change in photic environment can lead to an increased cell proliferation in the retina. We administered 5-chloro-2′ - deoxyuridine
(CldU) and 5-iodo-2′ -deoxyuridine (IdU) at different temporal windows to detect cell proliferation in natural light and permanent darkness. Stem/progenitor cells were recognized as IdU+/CldU + nuclei co-labeled with Sox2, Pax6 or BLBP found in the ciliary marginal zone (CMZ). The expression pattern of BLBP + glial cells and ultrastructural analysis indicates that CMZ has different cell progenitors. In darkness, the number of dividing cells significantly increased, compared to light conditions. Surprisingly, CMZ IdU+/CldU + cell number was similar under light and darkness, suggesting a stable pool of stem/progenitor cells possibly responsible for retinal growth. Therefore, darkness stimulated cell progenitors outside the CMZ, where Müller glia play a crucial role to
generate rod precursors and other cell types that might integrate rod-dependent circuits to allow darkness adaptation. Thus, the Austrolebias fish retina shows great plasticity, with cell proliferation rates significantly
higher than that of brain visual areas.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
Elsevier B.V.
EN:
Current Research in Neurobiology, 2022, 3: 100042.
Financiadores:
Citación:
Berrosteguieta Rodríguez, I, Rosillo Martí, J, Herrera, M, [y otros autores]. "Plasticity of cell proliferation in the retina of Austrolebias charrua fish under light and darkness conditions". Current Research in Neurobiology. [en línea] 2022, 3, 100042.16 h. DOI:10.1016/j.crneur.2022.100042
Citación:
metadata.articulos.cc.license.name:
ISBN:
e-ISBN:
ISSN:
2665-945X
ISMN:
Otros identificadores:
Cobertura geográfica:
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 101016jcrneur2022100042.pdf | — | 13.39 MB | Adobe PDF |