Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/38351
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dc.contributor.author Autor Vázquez Alberdi, Lucía-
dc.contributor.author Autor Martínez Busi, Marcela-
dc.contributor.author Autor Echeverry, Carolina-
dc.contributor.author Autor Calero, Miguel-
dc.contributor.author Autor Kun González, Alejandra E.-
dc.contributor.filiacion Filiación Vázquez Alberdi Lucía, IIBCE-
dc.contributor.filiacion Filiación Martinez Marcela, IIBCE-
dc.contributor.filiacion Filiación Echeverry Carolina, IIBCE-
dc.contributor.filiacion Filiación Calero Miguel-
dc.contributor.filiacion Filiación Kun González Alejandra E., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología.-
dc.date.accessioned Fecha ingreso 2023-07-24T13:37:35Z-
dc.date.available Fecha disponible 2023-07-24T13:37:35Z-
dc.date.issued Año de publicación 2023-
dc.description Descripción Enviado a Chemical Engineering Journal para su evaluación.es
dc.description.abstract Resumen Curcumin is a polyphenol extracted from the roots of the Curcuma longa plant. Low doses of curcumin are related to anti-inflammatory, antioxidant and neuroprotective effects, while high doses are used for their lethality. This diversity of behaviors allows us to understand curcumin as a compound with hormetic action. Due to its hydrophobic character, curcumin is solubilized in organic compounds, about which we have recently reported undesirable effects on the viability and proliferation of primary cultures of Schwann cells. The use of nanoparticles as delivery systems has been shown to be a successful strategy for many compounds. In the present work we describe the structure of Polydopamine (PDA) nanoparticles, loaded or not with a low dose of curcumin (0.05 μM), which we characterized by transmission and scanning electron microscopy. We analyzed the curcumin-PDA turnover with UHPLC-MS, and describe two different hydrophobic forms of curcumin, released at different times from their PDA-carrier. An increased cell viability and proliferation was observed in endoneurial fibroblast primary cell culture, when a low dose of curcumin-PDA was steadily supplied by prolonged periods. Furthermore, PDA alone as a vehicle showed no effect on viability and proliferation, in the same conditions. These results confirm the beneficial properties of curcumin at very low doses, thus widening its therapeutic window thanks to the increased bioavailability provided by our biological approach.es
dc.description.sponsorship Financiadores ANII: FCE_1_2019_1_155539es
dc.format.extent Extensión 18 hes
dc.format.mimetype Formato application/pdfes
dc.identifier.citation Citación Vázquez Alberdi, L, Martinez Busi, M.,Echeverry, C, Calero, M y Kun González, A. "Low hormetic dose of curcumin-PDA nanoparticles improves viability and proliferation in cell culture" [Preprint] 2023. 18 h.es
dc.identifier.uri URI https://hdl.handle.net/20.500.12008/38351-
dc.language.iso Idioma enes
dc.rights Derechos Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)es
dc.rights.licence Licencia Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)es
dc.subject Palabras clave Curcumines
dc.subject Palabras clave Polydopamine-Nanoparticleses
dc.subject Palabras clave Hormesises
dc.subject Palabras clave Viabilityes
dc.subject Palabras clave Proliferationes
dc.title Título Low hormetic dose of curcumin-PDA nanoparticles improves viability and proliferation in cell culturees
dc.type Tipo de documento Preprintes

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