Título:
H3 and H4 Lysine acetylation correlates with developmental and experimentally induced adult experience-dependent plasticity in the mouse visual cortex
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Autor:
Vierci, Gabriela
Pannunzio, Bruno
Bornia De León, Natalia
Rossi, Francesco Mattia
Pannunzio, Bruno
Bornia De León, Natalia
Rossi, Francesco Mattia
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Tipo de documento:
Artículo
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Palabras clave:
Visual cortex plasticity
Histone acetylation
Vesicular transporters
Development
Fluoxetine
Enriched environment
Histone acetylation
Vesicular transporters
Development
Fluoxetine
Enriched environment
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Año de publicación:
2016
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Resumen:
Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment). We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC
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Libertas Academica
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Journal of Experimental Neuroscience, 2016, 10 (s1): 49-64
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Citación:
Vierci, G., et al. H3 and H4 Lysine acetylation correlates with developmental and experimentally induced adult experience-dependent plasticity in the mouse visual cortex. Journal of Experimental Neuroscience, 2016, 10 (s1): 49-64.doi: 10.4137/JEN.S39888
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https://hdl.handle.net/20.500.12008/22065
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ISSN:
1179-0695
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Licencia Creative Commons Atribución – No Comercial (CC -BY-NC 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 104137JENS39888.pdf | — | 2.78 MB | Adobe PDF |