Título:
Facing diseases caused by Trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands
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Autor:
Gambino, Dinorah
Otero, Lucía
Otero, Lucía
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
ANTIPARASITARIOS
PARASITOS TRIPANOSOMATIDOS
PALADIO
PLATINO
PARASITOS TRIPANOSOMATIDOS
PALADIO
PLATINO
Descriptores:
Año de publicación:
2022
Contenido:
Resumen:
Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis (CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites belonging to the kinetoplastid order and they constitute an urgent global health problem. In fact, there is an urgent need of more efficient and less toxic chemotherapy for these diseases. Medicinal inorganic chemistry currently offers an attractive option for the rational design of new drugs and, in particular, antiparasitic ones. In this sense, one of the main strategies for the design of metal-based antiparasitic compounds has been the coordination of an organic ligand with known or potential biological activity, to a metal centre or an organometallic core. Classical metal coordination complexes or
organometallic compounds could be designed as multifunctional agents joining, in a single molecule, different chemical species that could affect different parasitic targets. This review is focused on the rational design of palladium(II) and platinum(II) compounds with bioactive ligands as prospective drugs against trypanosomatid parasites that has been conducted by our group during the last 20 years.
Descripción:
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Editorial:
Frontiers Media
EN:
Frontiers in chemistry v.9, 2022. -- e816266
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Citación:
Gambino, D y Otero, L. "Facing diseases caused by Trypanosomatid parasites: rational design of Pd and Pt complexes with bioactive ligands". Frontiers in chemistry. [en línea] 2022, 9: e816266, doi: 10.3389/fchem.2021.816266
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| AA Gambino, Dinorah. Frontiers in Chemistry, v.9, 2022. -- e816266.pdf | — | 1.51 MB | Adobe PDF |