Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/49606

Título:

Blood matters: the hematological signatures of Coronavirus infection

Otros títulos:

Coordinador:

Director:

Compilador:

Autor:

Toro, Ayelen
Arévalo, Ana Paula
Pereira-Gómez, Marianoel
Sabater, Agustina
Zizzi, Eric A.
Perbolianachis Duarte, Paula
Pascual, Gastón
Lage-Vickers, Sofia
Pórfido Barayoli, Jorge Luis
Achinelli, Ines
Seniuk, Rocio
Bizzotto, Juan
Sanchis, Pablo
Olivera, Álvaro
Leyva, Alejandro
Moreno Karlen, María del Pilar
Costábile Cristech, Alicia
Fajardo Rossi, Álvaro
Carrión Runco, Federico Daniel
Fló Díaz, Martín
Olivero-Deibe, Natalia
Rodríguez, Fernando
Nin, Nicolás
Anselmino, Nicolás
Labanca, Estefania
Vazquez, Elba
Cotignola, Javier
Alonso, Daniel F.
Marti, Marcelo
Valacco, María Pía
Gentile, Francesco
Cherkasov, Artem
Crispo, Martina
Moratorio, Gonzalo
Gueron, Geraldine

Tutor:

Tipo de documento:

Artículo

Editor:

Palabras clave:

Infection
Viral infection
SARS-CoV-2

Descriptores:

Año de publicación:

2024

Contenido:

Resumen:

Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through hemeinteracting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for intervention

Descripción:

Información suplementaria en: 10.1038/s41419-024-07247-8.

metadata.articulos.dc.description.uri:

Editorial:

Nature

EN:

Cell Death and Disease, 2024, 15: 863.

Financiadores:

Citación:

Toro, A, Arévalo, A, Pereira-Gómez, M [y otros autores]. "Blood matters: the hematological signatures of Coronavirus infection". Cell Death and Disease. [en línea] 2024, 15: 863. 13 h. DOI: 10.1038/s41419-024-07247-8

Citación:

metadata.articulos.cc.license.name:

ISBN:

e-ISBN:

ISSN:

2041-4889

ISMN:

Otros identificadores:

Cobertura geográfica:

Cobertura temporal:

Departamento académico:

Grupo de investigación:

Licencia:

Licencia Creative Commons Atribución (CC - By 4.0)

Colecciones:

Publicaciones académicas y científicas
FicherosDescripciónTamañoFormato
10.1038-s41419-024-07247-8.pdf — 5.43 MB Adobe PDF
Mostrar el registro Dublin Core completo del ítem