Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/43099

Título:

New insights into phenotype and genotype relationships in Neospora caninum

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Autor:

Cabrera Castro, Andrés M.
Berná, Luisa
López Rodríguez, Lucía
Faral-Tello, Paula
Arévalo, Ana Paula
Crispo, Martina
Francia, María Eugenia
Robello Porto, Carlos

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Tipo de documento:

Artículo

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Palabras clave:

Neospora caninum
Virulence
Chronicity
Vertical transmission
Abortion
Animal health
Single nucleotide polymorphisms

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Año de publicación:

2023

Contenido:

Resumen:

The successful isolation of four new Neospora caninum strains from different regions and with different backgrounds (obtained from an abortion storm or congenitally infected and asymptomatic calves) allowed us previously to characterize natural isolates, finding differences in phenotype and microsatellites. Given the variability observed, we wondered in this work whether these differences had consequences in virulence, invasion and vertical transmission using cell cultures and murine neosporosis models. In addition, we performed the genomic analysis and SNP comparative studies of the NcURU isolates. The results obtained in this work allowed us to establish that NcURU isolates are of low virulence and have unique phenotypic characteristics. Likewise, sequencing their genomes has allowed us to delve into the genetic singularities underlying these phenotypes, as well as the common mutated genes. This work opens a new perspective for diagnostic purposes and formulating possible vaccines based on attenuated strains.

Descripción:

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Editorial:

Frontiers

EN:

Frontiers in Veterinary Science, 2023, 10: 1214971.

Financiadores:

ANII: FSSA_X_2014_ 1_106026
ANII: FSSA_1_2019_1_160691

Citación:

Cabrera Castro, A, Berná, L, López Rodríguez, L [y otros autores]. "New insights into phenotype and genotype relationships in Neospora caninum". Frontiers in Veterinary Science. [en línea] 2023, 10: 1214971. 9 h. DOI: 10.3389/fvets.2023.1214971.

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ISSN:

2297-1769

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones académicas y científicas
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