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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Araujo, Lucía | - |
dc.contributor.author | Papa-Ezdra, Romina | - |
dc.contributor.author | Ávila, Pablo | - |
dc.contributor.author | Iribarnegaray, Victoria | - |
dc.contributor.author | Bado, Inés | - |
dc.contributor.author | Telechea, Hector | - |
dc.contributor.author | Garcia-Fulgueiras, Virginia | - |
dc.contributor.author | Vignoli, Rafael | - |
dc.date.accessioned | 2024-02-09T18:05:39Z | - |
dc.date.available | 2024-02-09T18:05:39Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | ARAUJO, L., PAPA-EZDRA, R., AVILA, P., y otros. Great Plasticity in a Great Pathogen: Capsular Types, Virulence Factors and Biofilm Formation in ESBL-Producing Klebsiella pneumoniae from Pediatric Infections in Uruguay. Antibiotics [en línea] v.13, 2024. DOI: 10.3390/antibiotics13020170 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12008/42420 | - |
dc.description.abstract | Klebsiella pneumoniae is widely recognized as an opportunistic hospital and community pathogen. It is one of the priority microorganisms included in the ESKAPE group, and its antibiotic resistance related to extended-spectrum β-lactamases (ESBL) is a global public health concern. The multi-drug resistance (MDR) phenotype, in combination with pathogenicity factors, could enhance the ability of this pathogen to cause clinical infections. The aim of this study was to characterize pathogenicity factors and biofilm formation in ESBL-producing K. pneumoniae from pediatric clinical infections. Capsular types, virulence factors, and sequence types were characterized by PCR. Biofilm formation was determined by a semiquantitative microtiter technique. MDR phenotype and statistical analysis were performed. The K24 capsular type (27%), virulence factors related to iron uptake fyuA (35%) and kfuBC (27%), and sequence types ST14 (18%) and ST45 (18%) were the most frequently detected. Most of the strains were biofilm producers: weak (22%), moderate (22%), or strong (12%). In 62% of the strains, an MDR phenotype was detected. Strains with K24 capsular type showed an association with ST45 and the presence of fyuA; strains with kfuBC showed an association with moderate or strong biofilm production and belonging to ST14. Weak or no biofilm producers were associated with the absence of kfuBC. The MDR phenotype was associated with the main ESBL gene, blaCTX-M-15. The high plasticity of K. pneumoniae to acquire an MDR phenotype, in combination with the factors exposed in this report, could make it even more difficult to achieve a good clinical outcome with the available therapeutics. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | en | es |
dc.relation.ispartof | Antibiotics. v. 13, 2024 | es |
dc.rights | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
dc.subject | Klebsiella pneumoniae | es |
dc.subject | ESBL | es |
dc.subject | K-types | es |
dc.subject | FyuA | es |
dc.subject | kfuBC | es |
dc.subject | biofilm | es |
dc.subject | ST | es |
dc.subject | MDR | es |
dc.subject | Pediatric-infections | es |
dc.title | Great Plasticity in a Great Pathogen: Capsular Types, Virulence Factors and Biofilm Formation in ESBL-Producing Klebsiella pneumoniae from Pediatric Infections in Uruguay | es |
dc.type | Artículo | es |
dc.contributor.filiacion | Araujo Lucía, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
dc.contributor.filiacion | Papa-Ezdra Romina, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
dc.contributor.filiacion | Ávila Pablo, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
dc.contributor.filiacion | Iribarnegaray Victoria, Ministerio de Educación y Cultura (Uruguay). Instituto de Investigaciones Biológicas Clemente Estable. Departamento de Microbiología | - |
dc.contributor.filiacion | Bado Inés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
dc.contributor.filiacion | Telechea Hector, Universidad de la República (Uruguay). Facultad de Medicina. Unidad Cuidados Intensivos Pediátricos | - |
dc.contributor.filiacion | Garcia-Fulgueiras Virginia, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
dc.contributor.filiacion | Vignoli Rafael, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
dc.rights.licence | Licencia Creative Commons Atribución (CC - By 4.0) | es |
dc.identifier.doi | 10.3390/antibiotics13020170 | - |
Aparece en las colecciones: | Artículos - Instituto de Higiene |
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Great Plasticity in a Great Pathogen Capsular Types.pdf | Artículo original | 956,59 kB | Adobe PDF | Visualizar/Abrir |
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